Estimating incidence of sexually transmissible infections in Australia

Authors

  • Ewan Cameron School of Mathematical Sciences, Queensland University of Technology, Queensland
  • Chris C. Drovandi School of Mathematical Sciences, Queensland University of Technology, Queensland
  • Jannah Baker School of Mathematical Sciences, Queensland University of Technology, Queensland
  • Wei Xian Lim School of Mathematical Sciences, University of Adelaide, South Australia
  • James Urquhart School of Mathematical Sciences, Queensland University of Technology, Queensland
  • Laith Yakob School of Population Health, The University of Queensland, Queensland
  • James M. McCaw Melbourne School of Population and Global Health \& Murdoch Childrens Research Institute, The University of Melbourne, Victoria

DOI:

https://doi.org/10.21914/anziamj.v55i0.8921

Abstract

The reported numbers of notifiable sexually transmitted infections in Australia are subject to a myriad of biases and limitations, including demographic, clinical, behavioural, and temporal factors. As such, trends in reported diagnosis rates may not reflect trends in true underlying incidence, thereby confounding any direct interpretation of raw notification data for public health research. The development of new methods to determine the true incidence and prevalence of an infection is a critical step for furthering the understanding of disease in the population. Here we devise a statistical model for chlamydia testing, and apply it to routinely available data to estimate the true incidence and prevalence of chlamydia infection within the Australian population. We preview in-progress work towards a yet more sophisticated methodology and outline how the approach may be extended to provide estimates for a number of other bacterial sexually transmitted infections of public health importance. References
  • T. Vos, A. D. Flaxman, M. Naghavi, R. Lozano, C. Michaud, M. Ezzati, K. Shibuya, J. A. Salomon, and 348 coauthors. Years lived with disability (ylds) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the global burden of disease study 2010. The Lancet, 380(9859):2163–2196, Dec 2012. doi:10.1016/S0140-6736(12)61729-2
  • Communicable Disease Network Australia. National Notifiable Diseases Surveillance System (NNDSS). http://www.health.gov.au/internet/main/publishing.nsf/Content/cda-surveil-nndss-nndssintro.htm
  • United States Centres for Disease Control and Prevention. The Role of STD Detection and Treatment in HIV Prevention–-CDC Fact Sheet, 2012. http://www.cdc.gov/std/hiv/stdfact-std-hiv.htm
  • Australian Government Department of Health and Ageing. Second National Sexually Transmissible Infections Strategy 2010–2013, 2010. http://www.health.gov.au/internet/main/publishing.nsf/Content/ohp-national-strategies-2010-sti
  • The Kirby Institute. National Blood-borne Virus and Sexually Transmissible Infections Surveillance and Monitoring Report, 2011. The Kirby Institute, The University of New South Wales, Sydney, NSW 2052.
  • The Kirby Institute. HIV, Viral Hepatitis and Sexually Transmissible Infections in Australia Annual Surveillance Report, 2012. The Kirby Institute, The University of New South Wales, Sydney, NSW 2052.
  • M. Y. Chen, M. Karvelas, V. Sundararajan, J. S. Hocking, and C. K. Fairley. Evidence for the effectiveness of a chlamydia awareness campaign: increased population rates of chlamydia testing and detection. International Journal of STD and AIDS, 18(4):239–243, 2007. doi:10.1258/095646207780658854
  • P. M. Konowitz, G. A. Petrossian, and D N. Rose. The underreporting of disease and physicians' knowledge of reporting requirements. Public Health Reports, 99(1):31–35, 1984. http://www.ncbi.nlm.nih.gov/pubmed/6422492
  • P. S. Mead, L. S., V. D., L. F. McCaig, J. S. Bresee, C. Shapiro, P. M. Griffin, and R. V. Tauxe. Food-related illness and death in the United States. Emerging Infectious Diseases, 5(5):607–625, 1999. doi:10.3201/eid0505.990502
  • R. Marier. The reporting of communicable diseases. American Journal of Epidemiology, 105(6):587–590, Jun 1977. http://www.ncbi.nlm.nih.gov/pubmed/868863
  • M. C. Kaczmarek, L. Valenti, H. A. Kelly, R. S. Ware, H. C. Britt, and S. B. Lambert. Sevenfold rise in likelihood of pertussis test requests in a stable set of Australian general practice encounters, 2000–2011. The Medical Journal of Australia, 198(11):624–628, 2013. doi:10.5694/mja13.10044
  • D. A. Cohen, M. Nsuami, D. H. Martin, and T. A. Farley. Repeated school-based screening for sexually transmitted diseases: a feasible strategy for reaching adolescents. Pediatrics, 104(6):1281–1285, Dec 1999. doi:10.1542/peds.104.6.1281
  • Royal Australian College of General Practitioners. Guidelines for preventive activities in general practice. 8th edition. Royal Australian College of General Practitioners, East Melbourne, Australia, 2012.
  • J. E. van Bergen, J. J. Kerssens, F. G. Schellevis, T. G. Sandfort, T. T. Coenen, and P. J. Bindels. Sexually transmitted infection health-care seeking behaviour in the Netherlands: general practitioner attends to the majority of sexually transmitted infection consultations. International Journal of STD and AIDS, 18(6):374–379, 2007. doi:10.1258/095646207781024883
  • C. H. Mercer, L. Sutcliffe, A. M. Johnson, P. J. White, G. Brook, J. D. C. Ross, J. Dhar, P. Horner, and 7 coauthors. How much do delayed healthcare seeking, delayed care provision, and diversion from primary care contribute to the transmission of STIs? Sexually Transmitted Infections, 83(5):400–405, 2007. doi:10.1136/sti.2006.024554
  • J. S. Hocking, M. S. C. Lim, J. Vidanapathirana, T. R. H. Read, and M. Hellard. Chlamydia testing in general practice–-a survey of Victorian general practitioners. Sexual Health, 3(4):241–244, Dec 2006. doi:10.1071/SH06042
  • R. L. Cook, S. L. Hutchison, L. \T1\O stergaard, R. S. Braithwaite, and R. B. Ness. Systematic review: noninvasive testing for chlamydia trachomatis and neisseria gonorrhoeae. Annals of Internal Medicine, 142(11):914–925, Jun 2005. doi:10.7326/0003-4819-142-11-200506070-00010
  • S. A. Morre, A. J. C. van den Brule, L. Rozendaal, A. J. P. Boeke, F. J. Voorhorst, S. de Blok, and C. J. L. M. Meijer. The natural course of asymptomatic Chlamydia trachomatis infections: 45% clearance and no development of clinical pid after one-year follow-up. International Journal of STD and AIDS, 13(1):12–18, 2002. doi:10.1258/095646202762226092
  • Australian Bureau of Statistics. Australian Demographic Statistics. Australian Bureau of Statistics, Canberra, Australia, 2013. http://www.abs.gov.au/ausstats/abs@.nsf/mf/3101.0
  • R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria, 2013. http://www.R-project.org

Published

2014-12-13

Issue

Section

Proceedings of the Mathematics in Industry Study Group