Computational Modelling of Cardiac Trabecula Mechanics


  • Alison Schroeder University of Auckland
  • Thiranja P Babarenda Gamage University of Auckland
  • Vicky Wang University of Auckland
  • Denis S Loiselle University of Auckland
  • Poul M F Nielsen University of Auckland
  • David P Nickerson University of Auckland
  • Ming Cheuk University of Auckland
  • Andrew J Taberner University of Auckland
  • Martyn P Nash University of Auckland
  • Kenneth Tran University of Auckland



Cardiac trabeculae are thin strips of muscle within the ventricles that can be readily excised and used to investigate contractile mechanics of cardiac muscle. Recently, the Auckland Bioengineering Institute has developed a novel cardiac myometer that simultaneously measures force, length and shape of actively contracting isolated cardiac trabeculae. Here we have developed a muscle-specific computational model based on optical coherence tomography geometric surface data that replicates passive mechanics of trabecula. We hypothesised that the muscle's surface geometry data, in addition to force-length data, would improve the fit between the model simulated mechanics and the experimental data. The trabecula model was optimised using two different objective functions (muscle length or shape) driven by a pressure boundary condition. For both objective functions, there was a region of optimal parameters the optimiser tended towards but, due to the coupling between parameters, the ability to find the true optimal parameters was hindered. Due to the limitations of the data, we found that the addition of surface data did not improve parameter estimation and that using only the force-length data provided sufficient information to produce an optimal fit. References
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Author Biographies

Alison Schroeder, University of Auckland

Auckland Bioengineering Institute

Thiranja P Babarenda Gamage, University of Auckland

Auckland Bioengineering Institute

Vicky Wang, University of Auckland

Auckland Bioengineering Institute

Denis S Loiselle, University of Auckland

Auckland Bioengineering Institute and Department of Physiology

Poul M F Nielsen, University of Auckland

Auckland Bioengineering Institute

David P Nickerson, University of Auckland

Auckland Bioengineering Institute

Ming Cheuk, University of Auckland

Auckland Bioengineering Institute

Andrew J Taberner, University of Auckland

Auckland Bioengineering Institute

Martyn P Nash, University of Auckland

Auckland Bioengineering Institute

Kenneth Tran, University of Auckland

Auckland Bioengineering Institute





Proceedings Engineering Mathematics and Applications Conference